SRY-related high-mobility group box 9 (SOX9) alleviates cigarette smoke extract (CSE)-induced inflammatory injury in human bronchial epithelial cells by suppressing stromal interaction molecule 1 (STIM1) expression - Inflammation Research
Source : https://link.springer.com/article/10.1007/s00011-022-01576-0
Background and objective Chronic obstructive pulmonary disease (COPD) is a chronic airway disease with airflow limitation and abnormal inflammatory response. It has been verified that SOX9 plays a key role...
Conclusion: "To sum up, results here suggested that overexpression of SOX9 could mitigate inflammatory injury in CSE-treated bronchial epithelial cells by suppressing STIM1."
Differences of the Nasal Microbiome and Mycobiome by Clinical Characteristics of COPD Patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35487694/
doi: 10.15326/jcopdf.2021.0267. Online ahead of print. 1 Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States. 2 Department of Biostatistics, Harvard T.H. Chan School of Public Health,...
Conclusion: The taxonomical composition of the nasal biome is heterogeneous in COPD patients and may be explained in part by clinical characteristics.
Difference in survival between COPD patients with an impaired immune reaction versus an adequate immune reaction to seasonal influenza vaccination: The COMIC study
Source : https://www.resmedjournal.com/article/S0954-6111(22)00116-0/fulltext
To study the hypothesis that COPD patients who do not achieve seroprotective levels after influenza vaccination, are a less immune-competent group with a higher risk of morbidity and mortality.
Conclusion: In a large well-characterized COPD cohort only the minority of patients achieved seroprotective titers to H1N1 and H3N1 after the yearly influenza vaccination. While achieving seroprotection after vaccination can be considered a surrogate marker of being immunocompetent, this was not associated with lower morbidity and mortality....
Ambient heat exposure and COPD hospitalisations in England: a nationwide case-crossover study during 2007-2018 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35459745/
doi: 10.1136/thoraxjnl-2021-218374. Online ahead of print. 1 MRC Centre for Environment and Health, Imperial College London, London, UK [email protected]. 2 NHLI, Imperial College London National Heart and Lung Institute, London,...
Conclusion: Our study suggests that resources should be allocated to support the public health systems, for instance, through developing or expanding heat-health alerts, to challenge the increasing future heat-related COPD hospitalisation burden.
Prognostic value of key variables from cardiopulmonary exercise testing in patients with COPD: 42-month follow-up - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35461168/
1 Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, UFSCar, Rodovia Washington Luis, KM 235, Monjolinho, CEP: 13565-905, Sao Carlos, SP, Brazil. 2 Profesor Titular de Universidad, departamento...
Conclusion: Diminished exercise capacity and peak ventilation as well as ventilatory inefficiency are independent prognostic markers. Similar to patients with heart failure, CPET may be a valuable clinical assessment in the COPD population.