A randomized, crossover, placebo controlled, double blind trial of the effects of tiotropium-olodaterol on neuromuscular performance during exercise in COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35323052/
Exercise intolerance in COPD is associated with dyspnea, reduced inspiratory capacity (IC) and occurs with a neuromuscular "power reserve" i.e. an acute ability to increase isokinetic locomotor power. This power...
Conclusion/Relevance: Exercise intolerance in COPD is associated with dyspnea, reduced inspiratory capacity (IC) and occurs with a neuromuscular "power reserve" i.e. an acute ability to increase isokinetic locomotor power. This power reserve is associated with resting FEV1/FVC suggesting that treatments to target pulmonary function may protect...
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MATTHEW SHORE4yrInteresting article
Nonlinear Heart Rate Variability in Patients with Chronic Obstructive Pulmonary Disease and Changes after 4-week Comprehensive Inpatient Pulmonary Rehabilitation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35366220/
Cardiovascular disease is among the leading causes of mortality in chronic obstructive pulmonary disease (COPD). Nonlinear heart rate variability (NHRV) measures are markers and predictors of cardiovascular disease, particularly arrhythmias....
Relevance: Our aim was to investigate NHRV in patients with COPD and changes after pulmonary rehabilitation. 20-minute ECGs were used to compare NHRV (a) in 45 healthy individuals and 31 patients with COPD and (b) in 16 patients who completed rehabilitation versus 13 age- and sex-matched control patients
Tobacco use and respiratory symptoms among adults: Findings from the Longitudinal Population Assessment of Tobacco and Health (PATH) Study 2014-16
Source : https://academic.oup.com/ntr/advance-article/doi/10.1093/ntr/ntac080/6562762?login=false
AbstractIntroduction. We examined the relationship between current tobacco use and functionally-important respiratory symptoms.Methods. Longitudinal cohort stud
Conclusions: Past and current cigarette smoking drove functionally-important respiratory symptoms, while exclusive use of other tobacco products was largely not associated. However, the relation between e-cigarette use and symptoms was sensitive to adjustment for pack-years and symptom severity.
Understanding the role of long-acting muscarinic antagonists in asthma treatment
Source : https://www.annallergy.org/article/S1081-1206(22)00017-5/fulltext
Long-acting muscarinic antagonists (LAMAs) have been used in the treatment of obstructive pulmonary diseases for years. Long-acting muscarinic antagonists were previously mainly used as bronchodilators in chronic obstructive pulmonary disease,...
Conclusion/Relevance: This review summarizes the scientific evidence on the use of LAMAs in asthma and aims to provide a better understanding of the role of LAMAs in the asthma treatment care algorithm and the current gaps in our knowledge.
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35338095/
1 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Kentucky College of Medicine, Lexington, Kentucky; and Division of Pulmonary and Critical Care Medicine, Harrison Memorial...
Conclusions: Spirometry with bronchodilation is an important element in the accurate diagnosis of ACO and COPD. Spirometry performed without bronchodilator testing may lead to an estimated misclassification of ACO by 7.6% to 19.8% and overdiagnosis of COPD by 39%.