COPD Connect
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Remarkable response to personalized combination immunotherapy of nivolumab plus ipilimumab in an 84-year-old patient with locally advanced squamous cell carcinoma: a case report. - PubMed

Remarkable response to personalized combination immunotherapy of nivolumab plus ipilimumab in an 84-year-old patient with locally advanced squamous cell carcinoma: a case report. - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/42433238

A reduced-dose nivolumab and ipilimumab regimen was used in an octogenarian with advanced squamous cell carcinoma, focusing on safety and response.


A reduced-dose regimen of nivolumab 200 mg Q3W plus ipilimumab 50 mg Q6W was administered to an elderly patient with advanced squamous cell carcinoma, focusing on safety and response.

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Exacerbations often dominate clinical attention in COPD — but how consistently do you assess the day-to-day burden of stable COPD on patients' physical activity, emotional wellbeing, and ability to maintain independence between events?
  • 1mo
    Difficult to assess this when patient has multiple issues to discuss in short appointment time
  • 1mo
    Routinely. A lot of patients dismiss chronic cough or mild SOB while climbing stairs as something they have to live with, not even think of them as a possible exacerbation Show More

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Multimodule Human-Artificial Intelligence Collaboration Pipeline for Large Language Model-Assisted Thematic Analysis Across Digital Health Interview Studies: Comparative Evaluation Study. - PubMed

Multimodule Human-Artificial Intelligence Collaboration Pipeline for Large Language Model-Assisted Thematic Analysis Across Digital Health Interview Studies: Comparative Evaluation Study. - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/42398927

Explore human-AI collaboration in primary care, enhancing digital health studies. Opus excels in theme alignment, with Gemini and ChatGPT offering speed and usability trade-offs.


A human-AI pipeline aids thematic analysis in digital health, with Opus aligning best across conditions like interstitial lung disease; Gemini and ChatGPT offer trade-offs.

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How updated GOLD 2026 guidance is shaping long-term COPD control

GOLD 2026 reframes how long-term COPD control is approached in clinical practice. Beyond spirometry alone, the updated guidance places greater emphasis on sustained symptom control, exacerbation prevention, and preservation of functional capacity—recognizing that airflow limitation and day-to-day disease impact do not always move in parallel.

The 2026 update more clearly distinguishes between initial and follow-up treatment pathways and emphasizes identifying future risk earlier in the disease course. Even a single moderate exacerbation is recognized as a meaningful risk signal, reinforcing a proactive strategy focused on early initiation of maintenance therapy to stabilize disease and reduce future events rather than reacting to repeated exacerbations.

Bronchodilation remains central to COPD management under GOLD 2026. Dual long-acting bronchodilation (LABA + LAMA) is recommended as preferred initial therapy for high-risk Group E, rather than initiating triple therapy. GOLD 2026 does not recommend initiating treatment with triple therapy as routine initial management. Instead, inhaled corticosteroids are added selectively—primarily in patients with blood eosinophil counts ≥300 cells/µL—highlighting that ICS use is conditional and not part of universal initial management. Because many symptomatic patients fall within Groups B and E, sustained dual bronchodilation remains foundational to long-term disease control.

As GOLD 2026 places greater weight on longitudinal assessment across the disease continuum, integrating symptoms, exacerbation history, lung function, and functional capacity into routine follow-up remains essential.

Which GOLD 2026 updates have most influenced how you assess long-term COPD control? Where does long-acting bronchodilation fit into your current approach to maintaining control?

 

  • 1mo
    The current medical therapies are superior to those available 5 years ago. I appreciate use of dual bronchodilator treatment
  • 2mo
    I am glad that GOLD started looking more closely at patient-reported outcomes; earlier introduction of dual and triple therapy also makes sense as exacerbation can lead to such poor health Show More

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Climate change and respiratory health: implications for respiratory clinicians in primary and specialist care. - PubMed

Climate change and respiratory health: implications for respiratory clinicians in primary and specialist care. - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41723176

Discover how climate change affects chronic respiratory diseases and the importance of optimal management in reducing their environmental impact.


Effective control of chronic respiratory diseases reduces their carbon footprint, especially if poorly controlled. Personalised inhaler choices also matter.