1yr
COPD Connect
1yr
Adherence to single inhaler triple therapy and digital inhalers in Chronic Obstructive Pulmonary Disease: a literature review and protocol for a randomized controlled trial (TRICOLON study) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38965541/
NCT05495698 (Clinicaltrials.gov), registered at 08-08-2022. Protocol version: version 5, date 27-02-2023.
Medication non-adherence in COPD is addressed through single-inhaler triple therapy and smart inhalers. The TRICOLON trial will assess their effectiveness on adherence and clinical outcomes in a randomized study.
1yr
Inhaler Adherence in COPD: A Crucial Step Towards the Correct Treatment - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38059011/
COPD is a typical example of chronic disease. As such, treatment adherence tends to be as low as between 30% and 50%, with specific issues in COPD due to the...
Low treatment adherence in COPD, especially with inhalers, worsens outcomes. Simplified regimens and smart inhalers could enhance adherence, improving long-term results by addressing patient, clinician, and system-related barriers.
1yr
Efficacy of Biologics in Patients with Allergic Severe Asthma, Overall and by Blood Eosinophil Count: A Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37698716/
Patients with uncontrolled, allergic severe asthma may be prescribed biologic therapies to reduce exacerbations and improve disease control. Randomized controlled trials (RCTs) of these therapies have differed in design, with...
In patients with allergic severe asthma, tezepelumab showed the greatest annualized asthma exacerbation rate reduction across all baseline eosinophil count categories, highlighting variability in biologic efficacy and treatment decisions.
1yr
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37658954/
Severe asthma in children and adolescents exerts a substantial health, financial, and societal burden. Severe asthma is a heterogeneous condition with multiple clinical phenotypes and underlying inflammatory patterns that might...
Severe asthma in children and adolescents poses significant health and financial burdens. This review explores recent developments in treatment, including biologics and potential biomarkers for improved treatment stratification.