COPD Phenotyping
Source : https://pubmed.ncbi.nlm.nih.gov/37353326/
COPD is a heterogeneous condition, the onset and trajectory of which is influenced not only by tobacco exposure but also an individual's genetics and the exposures they accumulate over their...
This review summarizes the evolution of COPD phenotyping, the current use of phenotyping to direct clinical care, and how innovations in clinical and molecular approaches to unraveling disease heterogeneity are refining our understanding of COPD phenotypes.
Implications of Cardiopulmonary Risk for the Management of COPD: A Narrative Review
Source : https://pubmed.ncbi.nlm.nih.gov/38664329/
Chronic obstructive pulmonary disease (COPD) constitutes a major global health burden and is the third leading cause of death worldwide. A high proportion of patients with COPD have cardiovascular disease,...
Reframing COPD management to focus on cardiopulmonary risk reduction can prevent serious events, reduce mortality, and transform care standards, leading to improved clinical outcomes for patients with COPD.
Towards precision medicine in COPD: Targeting type 2 cytokines and alarmins
Source : https://pubmed.ncbi.nlm.nih.gov/38762432/
Chronic obstructive pulmonary disease (COPD) is a main global epidemic increasing as population age and affecting approximately 10% of subjects over 45 years. COPD is a heterogeneous inflammatory disease with...
Targeting T2 inflammation and epithelial-derived alarmins in COPD may enhance precision medicine, improving patient outcomes and reducing healthcare costs by addressing exacerbation-related biomarkers and underlying pathobiology.
Obstructive Sleep Apnea and Acute Lower Respiratory Tract Infections: A Narrative Literature Review
Source : https://pubmed.ncbi.nlm.nih.gov/38927198/
Both obstructive sleep apnea (OSA) and acute lower respiratory tract infections (LRTIs) are important global health issues. The pathophysiological links between OSA and LRTIs include altered immune responses due to...
OSA increases the risk and severity of both bacterial and viral acute LRTIs, with no clear evidence of increasing pneumonia mortality. However, the relative contribution of chronic comorbidities to the risk and prognosis of LRTIs in OSA patients is not fully understood. Future research should focus on identifying OSA indices beyond AHI that...
Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review
Source : https://pubmed.ncbi.nlm.nih.gov/38929978/
Background/Objectives : Chronic Obstructive Pulmonary Disease (COPD) is a disease of premature aging, characterized by airflow limitations in the lungs and systemic chronic inflammation. This systematic review aimed to provide...
Considering the data available for this SR, our results indicate that changes associated with immunosenescence are observed in stable COPD patients, mainly increased IL-6 production and CD28null T cell frequencies and TL shortening in leukocytes. Although lung function severity was the disease marker most frequently analyzed in the studies,...