Delivering monoclonal antibodies via inhalation: A systematic review of clinical trials in asthma and COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37342873/
Compared to systemic administration, delivering mAbs via inhalation is associated with rapid onset of action, greater efficacy at lower doses, minimal systemic exposure, and lower risk of adverse events. Although...
Expert Opinion: Compared to systemic administration, delivering mAbs via inhalation is associated with rapid onset of action, greater efficacy at lower doses, minimal systemic exposure, and lower risk of adverse events. Although some of the inhaled mAbs included in this study showed a certain level of efficacy and safety in asthmatic...
Finding the Right Biological: Eosinophil Subset Differences in Asthma and COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37311240/
Finding the Right Biological: Eosinophil Subset Differences in Asthma and COPD
Summary: This paper provides important new insights into differences in the roles of eosinophils between COPD versus asthma, but predictably raises new questions, particularly regarding anatomic compartments. Rather than simply counting eosinophils, future studies should characterize subsets in both circulating and respiratory compartments....
Differential Response to 12 Weeks of Once-Daily Tiotropium/Olodaterol Fixed Dose Combination in Patients with COPD: A Multidimensional Response Profiling in the TORRACTO Study
Profiling the multidimensional response in patients receiving tiotropium/olodaterol using self-organizing maps
Conclusion: Individual responses on endurance time and pulmonary function after 12 weeks of T/O are heterogeneous. This study identified clusters in COPD patients with markedly different multidimensional response on LABD.
Associations of the inflammatory diet index and smoking status with the risk of chronic obstructive pulmonary disease and lung cancer
Source : https://pubs.rsc.org/en/content/articlelanding/2023/FO/D2FO03429H
It remains unknown whether a low-inflammatory diet could modify the chronic obstructive pulmonary disease (COPD) and lung cancer risk related to smoking. To investigate the association between a low-inflammatory diet,...
Conclusions/Relevance: Substituting equal intake of pro-inflammatory foods with anti-inflammatory foods is related to a decreased risk of COPD, but not lung cancer.
REALizing and improving management of stable COPD in China: results of a multicentre, prospective, observational study (REAL) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37318116/
The trial was registered on 20 March 2017 (ClinicalTrials.gov identifier: NCT03131362).
Conclusion: These results indicate a high burden of severe exacerbations and symptoms in Chinese outpatients with COPD, and low adherence with treatment guidelines, highlighting the need for more effective management nationwide.