Are We Missing the Opportunity to Disseminate GOLD Recommendations Through AECOPD Discharge Letters?
For decades, chronic obstructive pulmonary disease (COPD) has been placed among the leading causes of morbidity and mortality worldwide. Given the widespread exposure to risk factors for COPD, aging population...
Conclusion: Significant deficiencies in compliance with the GOLD guidelines were identified, translating into a missed opportunity for GPs to become acquainted with GOLD recommendations. These findings emphasize the necessity to increase compliance with guidelines first at specialist level and consequent standardization of DL.
Cognitive effects of individual anticholinergic drugs: a systematic review and meta-analysis
Source : https://www.scielo.br/j/dn/a/HChdKh69GXFpfKHdVYYnC6w/?lang=en
Anticholinergics (ACs) are among the most prescribed drugs. Investigating the impaired cognitive domains due to individual ACs usage is associated with controversial findings. The objective of this study was to...
Conclusion: Considering the limited number of well-designed RCTs, this systematic review found that glycopyrrolate, trospium, tolterodine, darifenacin, fesoterodine, tiotropium, and ipratropium are not associated with worsening of human cognition, but scopolamine, mecamylamine, atropine, biperiden, oxybutynin, trihexyphenidyl, benzhexol, and...
Use and persistence of single and multiple inhaler triple therapy prescribed for patients with COPD in France: a retrospective study on THIN database (OPTI study)
Source : https://bmjopenrespres.bmj.com/content/10/1/e001585
Introduction From 2018 single inhaler triple therapy (SITT) became available in France to treat moderate-to-severe chronic obstructive pulmonary disease (COPD). Given its simplified inhaler use compared with multiple inhaler triple...
Discussion: This study suggests that persistence was higher for the patients treated with SITT compared with MITT in France. Moreover, most patients initiated with triple therapy were previously treated with dual therapy and had exacerbations in the previous year.
Conclusion: In this cohort study, LAMA-LABA therapy was associated with improved clinical outcomes compared with ICS-LABA therapy, suggesting that LAMA-LABA therapy should be preferred for patients with COPD.
Epigenetic regulation of pulmonary inflammation
Source : https://www.sciencedirect.com/science/article/abs/pii/S108495212300112X?via=ihub
Among epigenetic modifications in proteins, methylation and acetylation are common. Modifications to histones is by far the most common occurrence and has been investigated in greater lengths. In recent studies...
Conclusions/Relevance: Epigenetic changes such as DNA methylation are stable and often long term and cause onset of chronic lung conditions. These epigenetic pathways are also being utilized for therapeutic intervention in several lung conditions.