Recognizing and tackling inhaler technique decay in asthma and COPD clinical practice - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37146881/
Poor inhaler technique continues to represent a substantial barrier to effective asthma and chronic obstructive pulmonary disease (COPD) management. It can result in perceived lack of treatment effectiveness even with...
Conclusions/Relevance: In this review, we present an overview of the evidence for deterioration of inhaler technique over time following training, investigate the factors that contribute to this deterioration, and explore innovative approaches to addressing the problem. We also propose steps forward drawn from the literature and our clinical...
Aerosol Pulmonary Immune Engineering
Source : https://www.sciencedirect.com/science/article/pii/S0169409X23001461?via=ihub
Available online 24 April 2023, 114831 Author links open overlay panel Emma R. Sudduth 1 , Michael Trautmann-Rodriguez 1 , Nicole Gill , Kartik Bomb , Catherine A. Fromen Show...
Conclusions/Relevance: In each section, we address the formulation design constraints for aerosol delivery as well as advantages for each platform in driving desirable immune modifications. Finally, prospects of clinical translation and outlook for inhaled immune engineering are discussed.
Advanced pathophysiology mimicking lung models for accelerated drug discovery - Biomaterials Research
Source : https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-023-00366-x
Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced...
Conclusion: Our model can be utilised to test safety, efficacy, and superiority of new therapeutics as well as to test toxicity and injury induced by inhaled pollution or pathogens. It is envisaged that these models can also be used to test the protective function of new therapeutics for high-risk patients or workers exposed to occupational...
Automated Oxygen Administration Alleviates Dyspnea in Patients Admitted with Acute Exacerbation of COPD: A Randomized Controlled Trial
In patients with Chronic Obstructive Pulmonary Disease (COPD), acute exacerbations are a major cause of hospitalizations, and in most cases associated with dyspnea, anxiety, and hypoxemia. Supplemental oxygen is a...
Conclusion: AOA reduces both breathing discomfort and physical perception of dyspnea in patients admitted with AECOPD but did not seem to impact the emotional status or other COPD symptoms.
Cognitive impairment according to Montreal Cognitive Assessment independently predicts the ability of chronic obstructive pulmonary disease patients to maintain proper inhaler technique - BMC Pulmonary Medicine
Source : https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-023-02448-x
Background Maintaining correct inhaler technique is crucial in the management of chronic obstructive pulmonary disease (COPD). We aimed to investigate the inhaler technique in patients with COPD, to compare it...
Conclusions: Face-to-face training by pharmacists improved patient performance. However, the number of patients following proper technique had decreased at 1 month after training. Cognitive impairment (MoCA score ≤ 16) independently predicted the ability of COPD patients to maintain proper inhaler technique. Assessment of cognitive...