High versus Medium Dose of Inhaled Corticosteroid in Chronic Obstructive Lung Disease: A Systematic Review and Meta-Analysis
Chronic obstructive pulmonary disease (COPD) is a medical condition that has a significant morbidity, mortality and financial toll globally. Since their first iteration, the Global Initiative for Chronic Obstructive Lung...
Conclusion: Our study collected RCTs investigating the optimal dosing level of ICS prescribed alongside ancillary bronchodilators to patients with COPD. We identified that the high ICS dose neither reduces AECOPD risk and mortality rates nor increases pneumonia risk relative to the medium dose.
A New Questionnaire to Assess Respiratory Symptoms (The Respiratory Symptom Experience Scale): Quantitative Psychometric Assessment and Validation Study
Source : https://formative.jmir.org/2023/1/e44036
Background: Smokers often experience respiratory symptoms (eg, morning cough), and those who stop smoking, including those who do so by switching completely to electronic nicotine delivery systems (ENDS), may experience...
Conclusions: The RSES fills an important gap in the existing toolkit of respiratory symptom questionnaires; it is a reliable and valid tool to assess respiratory symptoms in adult current and former smokers, including those who have switched to noncombusted nicotine products. This suggests that the scale is sensitive to respiratory symptoms...
Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
efficacy of AT in stable COPD patients. Methods: Randomized controlled trials (RCTs) for AT efficacy in stable COPD patients were searched in literature databases from the inception to December 31,...
Conclusion: AT is effective in improving lung function, quality of life and exercise capacity, and can be used as an adjunctive treatment in patients with stable COPD.
From the infant to the geriatric patient-Strategies for inhalation therapy in asthma and chronic obstructive pulmonary disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37054701/
Inhalation therapy represents the standard of care in children, adolescents as well as in young, middle-aged and geriatric adults with asthma or chronic obstructive pulmonary disease. However, there are only...
Conclusions/Relevance: An algorithm is developed that considers age and relevant comorbidities to support the decision-making process for the choice of an inhaler device.
Beta2-adrenoreceptor agonists and long-term risk of Parkinson's disease
Source : https://www.prd-journal.com/article/S1353-8020(23)00112-8/fulltext
Several studies have explored the role of β2-adrenoreceptor (β2AR) ligands in Parkinson's disease (PD). The β2AR is one of the main receptors for norepinephrine, which is released by neuronal projections...
Conclusion: Of drugs with the same indication of use, only β2AR agonists remained inversely associated with PD risk after all adjustments, with ultraLABA displaying the overall strongest association. Although the precision of the estimate is limited by the modest number of exposed PD cases without COPD, the association is intriguing and...