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Serum CXCL9 was significantly elevated in COPD compared to healthy controls and correlated with markers of epithelial injury and neutrophilic inflammation. Unlike ILD, higher CXCL9 in COPD reflected inflammatory burden rather than treatment responsiveness, highlighting disease-specific biomarker roles.
Source : https://pubmed.ncbi.nlm.nih.gov/41819537/
Aging is a crucial factor in the development of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. Marking the 10th anniversary of...
Review updates the hallmarks of lung aging, highlighting mechanisms such as cellular senescence, extracellular matrix dysregulation, inflammation, and environmental exposures that drive COPD and other chronic lung diseases.
Early-stage chronic obstructive pulmonary disease (COPD) may remain undetected when assessed using standard spirometric indices such as FEV₁ and the FEV₁/FVC ratio. This case-based report highlights the potential role of forced expiratory flow between 25% and 75% of vital capacity (FEF25–75) as a marker of small airway dysfunction.
In a 72-year-old former smoker presenting with exertional dyspnea and normal spirometry, a reduced FEF25–75 suggested early small airway involvement consistent with early COPD. Initial treatment with long-acting muscarinic antagonist (LAMA) monotherapy was associated with limited improvement. After escalation to dual bronchodilation with a LAMA–long-acting β₂-agonist (LABA) regimen, the patient experienced improvement in symptoms and spirometric parameters.
These findings highlight the potential value of evaluating small airway indices when symptoms persist despite normal conventional spirometry. In select cases, earlier recognition of small airway dysfunction may inform treatment strategies and symptom management.
Highlights:
What sets this study apart:
This report highlights the potential diagnostic contribution of FEF25–75 in symptomatic patients with normal spirometry and underscores the importance of considering small airway disease in early COPD evaluation.
Limitations:
Are you evaluating small airway indices such as FEF25–75 in patients with unexplained dyspnea but normal spirometry?
Source : https://pubmed.ncbi.nlm.nih.gov/41794937/
Chronic obstructive pulmonary disease (COPD) and osteoporosis are significant public health concerns, often co-occurring due to shared risk factors such as ageing, smoking, and systemic inflammation, as well as treatment-related...
NHANES analysis found COPD significantly associated with higher osteoporosis risk and lower bone mineral density, with stronger effects in males; prednisone use and sleep problems partially mediated this relationship.
Did you know? A meta-analysis of 17 RCTs in COPD (predominantly GOLD III–IV) found that adding non-invasive positive pressure ventilation (NPPV) to pulmonary rehabilitation improved 6MWD (+29 m), peak VO₂, respiratory muscle strength, and reduced dyspnea scores. Quality of life, however, showed no significant change.
Could integrating NPPV into pulmonary rehabilitation enhance functional gains in patients with severe COPD?
Could integrating NPPV into pulmonary rehabilitation enhance functional gains in patients with severe COPD?