Advances in phosphoproteomics and its application to COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36730079/
Phosphorylation is a posttranslational modification of proteins, a reversible process by which kinases translocate phosphate groups from ATP to protein residues, and phosphatases dephosphorylate proteins. The addition of phosphate groups...
Expert opinion: The role of phosphoproteomics in COPD is critical for understanding disease pathobiology, identifying potential biomarkers, and predicting new therapeutic approaches. However, the complexity of COPD requires the more comprehensive understanding that can be achieved through integrated multi-omics studies. Phosphoproteomics, as a...
Editorial: Palliative care for people living with heart and lung disease
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.1127688/full
One of the most relevant steps to provide optimal care (in any discipline, and any health-related problem), is timely recognition of the need of an appropriate intervention. Should it not...
Conclusions/Relevance: While much can still be done to improve quality of life during the dying phase, we advocate that disease modifying management incorporate care to assure the best possible quality of life by alleviating symptoms, ensuring compassionate communication, and support for spiritual and existential issues. We hope that this...
Real-World Evidence on the Diagnostic and Clinical Characteristics of Asthma in Japanese Patients with COPD: The ACO Japan Cohort Study
Chronic obstructive pulmonary disease (COPD) is a complex and progressive respiratory disease characterized by expiratory airflow limitation that is partially reversible, and with or without alveolar abnormalities. COPD symptoms are...
Conclusion: COPD patients with ACO determined by the JRS criteria had a high risk of exacerbations and a rapid decline in respiratory function, indicating that the JRS criteria for ACO are useful for identifying high-risk COPD patients. Testing necessary for ACO diagnosis is insufficiently performed even in real-world clinical practice of...
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Dr Hamid3yrChronic obstructive pulmonary disease (COPD) is a complex and progressive respiratory disease characterized by expiratory airflow limitation that is partially reversible, and with or without alveolar abnormalities
Clinical values of diaphragmatic movement in patients with chronic obstructive pulmonary disease - BMC Pulmonary Medicine
Source : https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-02220-7
Background The limitation of activity due to dyspnea in chronic obstructive pulmonary disease (COPD) patients is affected by diaphragmatic dysfunction and reduced lung function. This study aimed to analyze the...
Conclusion: The right diaphragmatic forced excursion was closely related to FEV1, and analysis according to the right diaphragmatic forced excursion-based cut-off value showed a significant difference between both groups. When the diaphragm function was maintained, there was a lot of difference in the 6MWT’s factors according to the FEV1...
Polycyclic aromatic hydrocarbon exposure burden: Individual and mixture analyses of associations with chronic obstructive pulmonary disease risk
Source : https://www.sciencedirect.com/science/article/abs/pii/S0013935123001263?via=ihub
Available online 24 January 2023, 115334 Author links open overlay panel Tian-Rui Gao b c 1 Wen-Jing Wang a Ping Zhan a Hui Zhao a Yichao Huang b Person c...
Conclusions/Relevance: Our results demonstrate the contemporary yet ongoing exposure burden of PAH exposure for over a decade, particularly towards NAPs and FLUs that contribute significantly to COPD risk, calling for more timely environmental regulation.