Risk of hospitalization in a sample of COVID-19 patients with and without chronic obstructive pulmonary disease
Source : https://www.resmedjournal.com/article/S0954-6111(22)00329-8/fulltext
Chronic lung conditions are risk factors for respiratory complications and community-acquired pneumonia [ ]. For example, patients with chronic obstructive pulmonary disease (COPD) have a >4-fold increased risk of pneumonia...
Conclusions: Except for hospitalization among patients using supplemental oxygen, no differences in odds of hospitalization or death/hospice referral were observed in the COVID-19 patient sample depending on whether they had COPD.
Mapping algorithms for predicting EuroQol-5D-3L utilities from the assessment test of chronic obstructive pulmonary disease - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-24956-2
To predict 3-Level version of European Quality of Life-5 Dimensions (EQ-5D-3L) questionnaire utility from the chronic obstructive pulmonary disease (COPD) assessment test (CAT), the study attempts to collect EQ-5D-3L and...
Conclusion: Response mapping with the MLR model led to performance comparable to the OLS and MRM models for predicting EQ-5D utility from CAT data. Additionally, the bubble charts analysis revealed that the model constructed in this study and MRM could be a better predictive model.
Lung deposition of inhaled once-daily long-acting muscarinic antagonists via standard jet nebulizer or dry powder inhaler, measured using functional respiratory imaging, in patients with chronic obstructive pulmonary disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35234085/
1 Theravance Biopharma US, Inc., South San Francisco, CA, USA (former)Clinical Pharma Specialist Consultants, LLC, Raleigh, NC, USA (current). 2 Theravance Biopharma US, Inc., 901 Gateway Boulevard, South San Francisco,...
Conclusions: These results demonstrate more efficient intrathoracic and peripheral deposition for revefenacin via standard jet nebulizer than tiotropium via HandiHaler, with similar C/P deposition ratio in patients with COPD. Nebulizers are an efficient alternative to DPIs for bronchodilator administration in patients with COPD.
Comparability of a provisioned device versus bring your own device for completion of patient-reported outcome measures by participants with chronic obstructive pulmonary disease: quantitative study findings - Journal of Patient-Reported Outcomes
Source : https://jpro.springeropen.com/articles/10.1186/s41687-022-00521-3
Objective To quantitatively compare equivalence and compliance of patient-reported outcome (PRO) data collected via provisioned device (PD) versus bring your own device (BYOD). Methods Participants with stable chronic obstructive pulmonary...
Conclusions: Measure completion was high and scores equivalent between PD and BYOD, supporting use of BYOD in addition to PD for collecting PRO data in COPD studies and in demographically diverse patient populations.
Persistence of RNA Viruses in the Respiratory Tract: An Overview - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36367976/
Respiratory RNA viruses are a major cause of acute lower respiratory tract infections and contribute substantially to hospitalization among infants, elderly, and immunocompromised. Complete viral clearance from acute infections is...
Relevance: We summarize evidence of RNA virus persistence in the human respiratory tract, as well as in some animal models, to highlight how long-term infections might be related to development and/or maintenance of chronic respiratory symptoms.