Annual decline rate in FEV1s in community-dwelling older adults diagnosed with mild to moderate COPD
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418326/
Information about the decline rate in forced expiratory volume in 1 s (FEV1s) in older adults with COPD is scarce. A total of 4082 community-dwelling older adults from the population-based study...
Conclusion/Relevance: Information about the decline rate in forced expiratory volume in 1 s (FEV1s) in older adults with COPD is scarce. A total of 4082 community-dwelling older adults from the population-based study Good Aging in Skåne were followed for 12 years and 143 participants developed COPD. The average FEV1s decline is estimated to...
Patients initiating single-inhaler LAMA/LABA dual therapy | COPD
Patients with chronic obstructive pulmonary disease (COPD) may start treatment with long-acting muscarinic antagonist/long-acting β 2-agonist (LAMA/LABA) dual therapy, a combination of two bronchodilator medications that work together to open...
Conclusions: Characteristics of patients newly initiating single-inhaler LAMA/LABA dual therapy were highly consistent across indexed therapies. As half of non-triple users were not receiving respiratory therapy one year prior to LAMA/LABA initiation, there may be an opportunity for early optimization of treatment to relieve clinical burden...
The effects of breathing exercises and inhaler training in patients with COPD on the severity of dyspnea and life quality: a randomized controlled trial - Trials
Source : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06603-3
Background Severe dyspnea and poor quality of life are common in chronic obstructive pulmonary disease (COPD). The most important reason for this is wrong applications in inhaler treatment. In addition,...
Conclusions: As a result of the study, it was found that the skill of using the inhaler and the life quality of the patients increased, and the severity of dyspnea decreased. Supporting inhaler treatments with non-pharmacological methods can increase drug efficacy and quality of life.
Optimization of Long-Acting Bronchodilator Dose Ratios Using Isolated Guinea Pig Tracheal Rings for Synergistic Combination Therapy in Asthma and COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36015111/
The co-administration of a long-acting β2-agonist (LABA), and a long-acting muscarinic antagonist (LAMA), has been shown to be beneficial in the management of non-communicable chronic respiratory diseases, such as asthma...
Conclusions: In this study, the LABAs formoterol fumarate dihydrate (FOR) and indacaterol maleate (IND) were each associated with tiotropium bromide monohydrate (TIO) to assess their synergistic potential.
Blood CDC42 overexpression is associated with an increased risk of acute exacerbation, inflammation and disease severity in patients with chronic obstructive pulmonary disease
Source : https://www.spandidos-publications.com/10.3892/etm.2022.11481
It has been previously reported that cell division control 42 (CDC42) protein can regulate macrophage recruitment, T cell‑associated inflammation and lung injury. However, its role in chronic obstructive pulmonary disease...
Conclusion: Data from the present study suggest that CDC42 is associated with an increased risk of acute exacerbation, inflammation and disease severity in patients with COPD, implicating its application as a potential biomarker for COPD.