Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Triple Therapy Compared with Other Therapies for the Treatment of COPD: A Network Meta-Analysis - Advances in Therapy
Source : https://link.springer.com/article/10.1007/s12325-022-02231-0
Introduction Randomized controlled trials (RCTs) comparing triple therapies (inhaled corticosteroid [ICS], long-acting β2-agonist [LABA], and long-acting muscarinic antagonist [LAMA]) for the treatment of chronic obstructive pulmonary disease (COPD) are limited....
Conclusion: The findings of this NMA suggest favorable efficacy with single-inhaler triple therapy comprising FF/UMEC/VI. Further analysis is required as additional evidence becomes available.
Asthma, bronchiectasis, and chronic obstructive pulmonary disease: the Bermuda Triangle of the airways - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35869863/
doi: 10.1097/CM9.0000000000002225. Online ahead of print. 1 Pneumology Department, Hospital Universitario y Politécnico la Fe de Valencia, Spain. 2 CIBERES de enfermedades respiratorias, Instituto de salud Carlos III, Madrid, Spain....
Relevance: Although asthma and COPD are well-known diseases for most physicians, bronchiectasis is less known. Bronchiectasis is characterized by the bronchial lumen dilatation due to the progressive destruction of the bronchial wall because of a vicious circle of airway inflammation and chronic infection.
Objective physical activity level is associated with rectus femoris muscle echo-intensity in patients with chronic obstructive pulmonary disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35869592/
doi: 10.1111/crj.13528. Online ahead of print. 1 Division of Rehabilitation, Akita University Hospital, Akita City, Japan. 2 Department of Rehabilitation, Akita City Hospital, Akita City, Japan. 3 Department of Physical...
Conclusion: The present study showed that PA level was associated with RF-EI in patients with COPD. In addition, RF-CSA was associated with knee extensor force. When assessing skeletal muscle using ultrasonography in patients with COPD, we should also assess EI.
Comparative Efficacy of Umeclidinium/Vilanterol Versus Other Bronchodilators for the Treatment of Chronic Obstructive Pulmonary Disease: A Network Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35857184/
UMEC/VI provided generally better outcomes compared with LAMA or LABA monotherapies, and consistent improvements in lung function (measured by change from baseline in trough FEV 1 at 24 weeks) versus...
Conclusion: UMEC/VI provided generally better outcomes compared with LAMA or LABA monotherapies, and consistent improvements in lung function (measured by change from baseline in trough FEV1 at 24 weeks) versus dual therapies. Treatment with UMEC/VI may improve outcomes for symptomatic patients with COPD compared with alternative maintenance...
Predictive modeling of COPD exacerbation rates using baseline risk factors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35815359/
These models predicting rates of moderate/severe exacerbations can be applied to a broad range of patients with COPD in terms of airway obstruction, eosinophil counts, exacerbation history, symptoms, and treatment...
Conclusion: These models predicting rates of moderate/severe exacerbations can be applied to a broad range of patients with COPD in terms of airway obstruction, eosinophil counts, exacerbation history, symptoms, and treatment history. Understanding the relative and absolute risks related to these factors may be useful for clinicians in...
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COPD Connect4yrKey Points • Source: Therapeutic Advances in Respiratory Disease • Relevance: “These models predicting rates of moderate/severe exacerbations can be applied to a broad range of patients with COPD in terms of Show More