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Rationale and Strategy for Switching to an All-Nebulization Protocol for In-Hospital Administration of Respiratory Medications - PubMed

Rationale and Strategy for Switching to an All-Nebulization Protocol for In-Hospital Administration of Respiratory Medications - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41523300/

Hospitalized patients with asthma or COPD typically receive respiratory medications via inhalers (pressurized metered dose inhalers, dry powder inhalers, or soft mist inhalers) or nebulizers. Because in-hospital use of inhalers...

Implementation-focused review describes rationale, benefits, and operational considerations for adopting all-nebulization protocols in hospitalized COPD patients to reduce inhaler-related errors, streamline formulary management, and improve inpatient respiratory medication delivery.

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Mechanisms driving immunopathogenesis of viral exacerbations in chronic respiratory disease - PubMed

Mechanisms driving immunopathogenesis of viral exacerbations in chronic respiratory disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41482480/

Collectively, these interconnected factors create a permissive environment predisposing to viral infection and exacerbations in chronic respiratory diseases. Understanding the complex interactions between airway structure, interferon-mediated antiviral responses, inflammation and...

Review examines immunopathogenic mechanisms underlying virus-driven exacerbations in chronic respiratory diseases, highlighting airway epithelial dysfunction, impaired interferon responses, inflammation, and microbiome dysbiosis as key contributors to COPD exacerbations.

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Strengthening COPD onboarding: From first training to lasting adherence

In recent studies, more than 50% of patients with COPD could not correctly demonstrate their inhaler technique just weeks after initiation—even when they left the clinic confident in their skills. This reflects the challenges of managing a lifelong respiratory condition amid complex devices and fluctuating symptoms.

Structured onboarding can shift that trajectory. Using “teach-to-goal” (ie, repeated practice until correct use is demonstrated) and scheduling follow-up checks within weeks have been linked to improved control scores and fewer exacerbations. Brief refreshers at each encounter—during vitals or while updating the EMR—can help reinforce proper technique.

But effective education must go beyond technique. The patient journey includes emotional stages. Some patients are eager to master their device; others may be anxious, in denial, frustrated, or discouraged. Providing tailored education on flare-up management, treatment milestones, and integrating therapy into daily life can improve engagement. Addressing practical barriers such as cost, forgetfulness, or lack of support further supports long-term adherence.

During a busy COPD follow-up, where do you find time for a quick but effective inhaler technique review? How have you adapted your approach for patients who resist repeated inhaler education?

  • 1mo
    So often times I found the double team approach to be effective. I usually have the nurse see if he has his device and demonstrate how to use it, then Show More
  • 2mo
    I can discuss this at their office visit and demonstrate how to do it or if they have their own inhaler I can have them demonstrate use for me. It Show More

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Distinct Plasma Proteome in Severe Pulmonary Hypertension Associated with Chronic Lung Disease - PubMed

Distinct Plasma Proteome in Severe Pulmonary Hypertension Associated with Chronic Lung Disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41391649/

The pathophysiological mechanisms underlying the development of PH differ between COPD and ILD, and the proteomic profile of severe PH in both conditions is distinct from that observed in iPAH.

Plasma proteomics revealed distinct molecular pathways underlying pulmonary hypertension severity in COPD and ILD, showing disease-specific extracellular matrix and immune signatures and profiles differing from idiopathic pulmonary arterial hypertension patterns.

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The role of preoperative lung rehabilitation training combined with nutritional intervention on surgical tolerance and accelerated recovery indicators in patients with moderate to severe COPD complicated with lung cancer - PubMed

The role of preoperative lung rehabilitation training combined with nutritional intervention on surgical tolerance and accelerated recovery indicators in patients with moderate to severe COPD complicated with lung cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41346729/

Preoperative lung rehabilitation training combined with nutritional intervention can effectively improve pulmonary function and respiratory function in patients with moderate to severe COPD complicated by lung cancer, enhance their surgical...

Combining preoperative lung rehabilitation with nutritional intervention improved pulmonary function, exercise capacity, blood gases, quality of life, and reduced postoperative complications in moderate–severe COPD patients undergoing lung cancer surgery compared with nutrition alone.