Small Airways: The "Silent Zone" of 2021 GINA Report?
Source : https://www.frontiersin.org/articles/10.3389/fmed.2022.884679/full
Asthma is a chronic disease, affecting approximately 350 million people worldwide. Inflammation and remodeling in asthma involve the large airways, and it is now widely accepted that the small airways...
Conclusion/Relevance: SAD appears to possess the characteristics of a treatable pulmonary trait, making it certainly appealing for asthma control optimization and exacerbation rate reduction. In this mini-review article, we address the most recent evidence on the role of SAD on asthma control and critically review the possible inclusion of SAD...
Tiotropium and treatable traits in ACO | JAA
Asthma is a common disorder with variable severity characterized by reversible airway obstruction, airway hyperresponsiveness (AHR), and chronic airway inflammation. According to worldwide surveys, approximately 350 million individuals currently suffer...
Conclusion: TIO add-on therapy to FP/FM in patients with ACO, considered difficult to treat because of the presence of both asthma and COPD, resulted in improvements in lung function parameters in this real-world pilot study, indicating the potential value of TIO add-on therapy as a “treatable traits” option for standard treatment for ACO.
Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative LEEP Trial
Source : https://www.atsjournals.org/doi/10.1164/rccm.202201-0206OC
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Conclusions: Losartan did not prevent emphysema progression in people with COPD with mild-moderate emphysema.
Effect of Yifei-Huoxue Decoction Combined with Tiotropium on Inflammatory Cytokine Levels, Pulmonary Function, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Source : https://www.hindawi.com/journals/cin/2022/5740181/
Objective . The main objective is to investigate the effect of Yifei-Huoxue decoction combined with tiotropium on the inflammatory cytokine levels, pulmonary function, and quality of life in patients with...
Relevance:
The main objective is to investigate the effect of Yifei-Huoxue decoction combined with tiotropium on the inflammatory cytokine levels, pulmonary function, and quality of life in patients with chronic obstructive pulmonary disease (COPD).
Effectiveness of COPD treatment with the combination of tiotropium/olodaterol in Polish standard clinical practice as measured by the improvement of CCQ: an observational study
Source : https://www.mp.pl/paim/issue/article/16268/
Introduction: COPD health-related quality of life (HRQoL) can be measured by the Clinical COPD Questionnaire (CCQ). In this study the CCQ was used to assess the therapeutic success of fixed-dose...
Conclusions:
Tiotropium/olodaterol treatment improved clinical control in Polish COPD patients. The therapeutic success was the most pronounced in patients with more severe COPD and in the treatment-naive but occurred also in those with moderate disease and in previously treated subjects.