COPD Connect
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4yr
Tiotropium Add-On and Treatable Traits in Asthma-COPD Overlap: A Real-World Pilot Study

Tiotropium Add-On and Treatable Traits in Asthma-COPD Overlap: A Real-World Pilot Study

Source : https://www.dovepress.com/tiotropium-add-on-and-treatable-traits-in-asthma-copd-overlap-a-real-w-peer-reviewed-fulltext-article-JAA

Asthma is a common disorder with variable severity characterized by reversible airway obstruction, airway hyperresponsiveness (AHR), and chronic airway inflammation. According to worldwide surveys, approximately 350 million individuals currently suffer...


Conclusions:
TIO add-on therapy to FP/FM in patients with ACO, considered difficult to treat because of the presence of both asthma and COPD, resulted in improvements in lung function parameters in this real-world pilot study, indicating the potential value of TIO add-on therapy as a “treatable traits” option for standard treatment for...

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4yr
Share your Opinion: LAMA inhalers for COPD

Maintenance bronchodilator treatments of chronic obstructive pulmonary disease (COPD) include oral inhaled long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABA). These agents attenuate COPD symptoms and decrease the severity/number of exacerbations. They also enhance quality of life and heighten exercise capacity.

Tiotropium is a LAMA and anticholinergic, with similar degrees of affinity to M1 to M5 subtypes of muscarinic receptors. At the level of the airways, this agent inhibits M3-receptors at the smooth muscle, thus resulting in bronchodilation. In in vitro and in vivo studies, prevention of methacholine-induced bronchoconstriction effects lasted greater than 24 hours and were dose-dependent, with bronchodilation being mostly site specific. In clinical trials, handheld LAMA inhalers exhibited peak efficacy within 3 hours after the first dose.

What has your clinical experience been with LAMA inhalers? What is patient satisfaction regarding treatment?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788262/
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021395s029lbl.pdf
https://pro.boehringer-ingelheim.com/us/products/spiriva/copd 
 




  • 4yr
    I dont manage the use of these as an ED physician but have found those on them in the community are managed quite well in terms of need for repeat Show More
  • 4yr
    Lots of success with them provided the patients start using before late stage is extremely important that the patients know how to use the inhalers properly - there Show More

Show More Comments

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made a Post

4yr
Share your Opinion: LAMA inhalers for COPD

Maintenance bronchodilator treatments of chronic obstructive pulmonary disease (COPD) include oral inhaled long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABA). These agents attenuate COPD symptoms and decrease the severity/number of exacerbations. They also enhance quality of life and heighten exercise capacity.



Tiotropium is a LAMA and anticholinergic, with similar degrees of affinity to M1 to M5 subtypes of muscarinic receptors. At the level of the airways, this agent inhibits M3-receptors at the smooth muscle, thus resulting in bronchodilation. In in vitro and in vivo studies, prevention of methacholine-induced bronchoconstriction effects lasted greater than 24 hours and were dose-dependent, with bronchodilation being mostly site specific. In clinical trials, handheld LAMA inhalers exhibited peak efficacy within 3 hours after the first dose.



What has your clinical experience been with LAMA inhalers? What is patient satisfaction regarding treatment?



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788262/

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021395s029lbl.pdf

https://pro.boehringer-ingelheim.com/us/products/spiriva/copd 

 


  • 4yr
    I dont manage the use of these as an ED physician but have found those on them in the community are managed quite well in terms of need for repeat Show More
  • 4yr
    Lots of success with them provided the patients start using before late stage is extremely important that the patients know how to use the inhalers properly - there Show More

Show More Comments

  • Saved

4yr
Evaluating electronic cigarette cytotoxicity and inflammatory responses in vitro - PubMed

Evaluating electronic cigarette cytotoxicity and inflammatory responses in vitro - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35611070/

1 Department of Biochemistry and Molecular Biology, Penn State College of Medicine, United States. 2 Department of Public Health Sciences, Penn State College of Medicine, United States. Free PMC article...


Conclusions: Our in vitro bioassays can be utilized to effectively measure flavor and nicotine-induced effects of e-cigarettes on combined inflammatory response and cytotoxicity in human macrophages and human bronchial epithelial cells, respectively.

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4yr
Patient Values Associated with an Exergame Supporting COPD Treatment - PubMed

Patient Values Associated with an Exergame Supporting COPD Treatment - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35612193/

Exercise games (exergames) can help COPD patients stay active and prevent exacerbation. When evaluating such exergames, patient values are an important variable to take into account. In this study, seven...


Relevance: Exercise games (exergames) can help COPD patients stay active and prevent exacerbation. When evaluating such exergames, patient values are an important variable to take into account. In this study, seven COPD patients used an exergame technology at the physiotherapist for six months. Their values regarding treatment and the exergames...