Inhaled Corticosteroids and the Risk of Nontuberculous Mycobacterial Pulmonary Disease in Chronic Obstructive Pulmonary Disease: Findings from a Nationwide Population-Based Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37511700/
Studies have shown increased nontuberculous mycobacterial pulmonary disease (NTM) incidence with inhaled corticosteroid (ICS) use in patients with chronic respiratory diseases; however, this association in chronic obstructive pulmonary disease (COPD)...
Conclusions/Relevance: ICS use may increase the risk of developing NTM disease in patients with COPD. Physicians should weigh the potential benefits and risks of ICS, especially when using high doses and prolonged durations.
Personalizing Selection of Inhaled Delivery Systems in COPD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37499210/
It can be challenging for health care professionals (HCPs) to prescribe inhaled therapy for patients with chronic obstructive pulmonary disease (COPD) due to the multiple individual and combinations of inhaled...
Conclusions/Relevance: Based on these findings, five questions are proposed for HCPs to consider in the initial selection of an inhaler delivery system and three questions to consider at follow-up. We propose that HCPs consider the inhaled medication-delivery system as a unit and to match an appropriate medication(s) with the unique features...
The Influence of Breathing Exercises on Regional Ventilation in Healthy and Patients with Chronic Obstructive Pulmonary Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37477218/
We hypothesized that the respiratory exercises have uniform effects on ventilation in healthy subjects but the effects varied in patients with chronic obstructive pulmonary disease (COPD). In this study, a...
Conclusions/Relevance: Although this trend was observed in the COPD, the differences were not significant. Ventilation became more homogeneous when diaphragmatic breathing technique was implemented (p < 0.0001). Again, the improvements were not significant in COPD. Regional ventilation delay was relatively high in COPD and comparable...
-
COPD Connect3yrKey Points • Source: COPD: Journal of Chronic Obstructive Pulmonary Disease • Discussion: “In the present study, we demonstrated the influences of breathing exercises on regional ventilation in healthy volunteers and subjects with COPD. Show More
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37458730/
Patient symptom relief is often heavily influenced by the residence time of the inhibitor-target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodilator used in conditions...
Conclusions/Relevance: Using our novel unbinding algorithm, we were able to investigate ligand dissociation from hMR3. The unbinding paths of tiotropium and two of its analogues, N-methylscopolamin and homatropine methylbromide, show a consistent qualitative mechanism and allow us to identify the structural bottleneck of the process....
Pre-diagnostic prescribing patterns in dyspnoea patients with as-yet-undiagnosed lung cancer: A longitudinal study of linked primary care and cancer registry data
Source : https://www.sciencedirect.com/science/article/pii/S1877782123001091?via=ihub
Patients with as-yet undiagnosed lung cancer (LC) can present to primary care with non-specific symptoms such as dyspnoea, often in the context of pre...
Conclusion: Results indicate that a diagnostic window of appreciable length exists for potential earlier LC diagnosis in some patients. Lung cancer diagnosis may be delayed if early symptoms are misattributed to COPD or other benign conditions.